PHM036En2.qxd
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Page 55
Morphine Intrathecal/Epidural Overdose
Consult the patient's medical record or with the patient's physician to confirm the
drug or drug concentration within the pump reservoir.
Symptoms:
Respiratory depression with or without concomitant central nervous system
depression (i.e, dizziness, sedation, euphoria, anxiety, seizures, respiratory
arrest
1
).
Actions:
access port or by lumbar puncture to reduce CSF morphine concentration.
Continue to monitor closely for symptom recurrence. Since the
duration of the effect of IV Naloxone is shorter than the effect of
intrathecal/epidural morphine, repeated administration
may be necessary.
No
Recurrence
Call physician:
Telephone:
1
Preservative-free Morphine Sulfate Sterile Solution manufacturer's package insert
2
Naloxone hydrochloride manufacturer's package insert
3
Refer to the drug manufacture's package insert for a complete list of indications, contraindications,
warnings, precautions, adverse events, and dosage and administration information.
Medtronic - Kerkrade / PARTNUMBER :
Appendix C: Emergency Procedures
Maintain Airway/Breathing/Circulation.
Respiratory resuscitation and intubation may be necessary.
Give Naloxone 0.4 - 2 mg intravenously.
If not contraindicated, withdraw 30 - 40 ml of CSF through the catheter
Use only a 25-gauge, 3.81 or 5.08 cm needle for withdrawal from
the catheter access port.
Empty pump reservoir to stop drug flow (see page 56).
Record amount withdrawn.
Response
Continue to perform life-
sustaining measures.
1
Recurrence
Repeat Naloxone every 2 - 3 minutes to maintain adequate respiration.
For continuous IV infusion see Naloxone package insert.
If no response is observed after 10 mg of Naloxone, the diagnosis of
narcotic-induced toxicity should be questioned.
(
)
Area Code
198076-036
55
1,2,3
No Response
1,2
2
1,2
SHEETNR. :